Some of the more frequently encountered types include common gamma chain deficiency, adenosine deaminase (ADA) deficiency, JAK 3 kinase deficiency, MHC class II deficiency, and recombinase activating gene (RAG) deficiency. The names given to the different types of SCID are based on the particular protein or gene that is affected. Recent developments in genetics mean that doctors are now often able to make a specific SCID diagnosis. In infants affected by SCID, a genetic mistake results in the absence or malfunction of a protein that is necessary for normal development and/or function of the immune system. Many different genes can be affected, each causing a different type of SCID. Specialists in genetics and genetic counselling are on hand to talk through the inheritance of SCID with families if needed, and we have a separate information leaflet devoted to the genetics of primary immunodeficiency available on our website. It is caused by a mistake (or mutation) in a child’s genetic make-up. SCID is an inherited condition, meaning it is passed on in families in the same way as physical characteristics, such as eye colour, are passed from parent to child. The three main types of lymphocytes that can be affected are called T-cells, B-cells and natural killer (‘NK’) cells. In all infants affected by SCID, specialised white blood cells, known as lymphocytes, are missing or not functioning properly. There are many different types of SCID, each with different genetic causes. However, infants affected by the various types of SCID have many features in common and these are described in this leaflet. Treatment is now available that can reduce the risk of serious infection, and in many cases, cure the disorder. Today, doctors understand much more about SCID. Affected infants become unwell within the first few months of life, and before modern medication and treatments were available, most affected babies did not survive beyond their first year. They form part of a larger group of conditions known as primary immunodeficiencies. The immune system abnormalities in SCID lead to greatly increased risks of infection and other complications that are life-threatening. PKU may be diagnosed by assaying a sample of blood or urine for phenylalanine or one of its metabolites.Severe combined immunodeficiency (SCID) is the name given to a group of rare, inherited disorders that cause major abnormalities of the immune system. Excessive amounts of phenylpyruvate impair normal brain development, which causes severe mental retardation. The disease acquired its name from the high levels of phenylpyruvate (a phenyl ketone) in urine. When this reaction cannot occur, phenylalanine accumulates and is then converted to higher than normal quantities of phenylpyruvate. Without this enzyme, a person cannot convert phenylalanine to tyrosine, which is the precursor of the neurotransmitters dopamine and norepinephrine as well as the skin pigment melanin. PKU results from the absence of the enzyme phenylalanine hydroxylase. Hypoxanthine-guanine phosphoribosyl transferaseĪntihemophilic factor (factor VIII) or Christmas factor (factor IX)īranched chain α-keto acid dehydrogenase complexįumarylacetoacetate hydrolase or tyrosine aminotransferase Galactose 1-phosphate uridyl transferase, galactokinase, or UDP galactose epimerase \): Some Representative Genetic Diseases in Humans and the Protein or Enzyme Responsible Disease
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